Deep brain stimulation in Parkinson's disease following fetal nigral transplantation
Identifieur interne : 002909 ( Main/Exploration ); précédent : 002908; suivant : 002910Deep brain stimulation in Parkinson's disease following fetal nigral transplantation
Auteurs : Jan Herzog [Allemagne] ; Oliver Pogarell [Allemagne] ; Marcus O. Pinsker [Allemagne] ; Andreas Kupsch [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Olle Lindvall [Suède] ; Günther Deuschl [Allemagne] ; Jens Volkmann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Deep Brain Stimulation (methods), Deep brain stimulation, Dyskinesia, Fetal Tissue Transplantation (methods), Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (surgery), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Substantia Nigra (transplantation), Transplantation, Treatment Outcome, deep brain stimulation, dyskinesias, neural transplantation.
- MESH :
- methods : Deep Brain Stimulation, Fetal Tissue Transplantation.
- surgery : Parkinson Disease.
- therapy : Parkinson Disease.
- transplantation : Substantia Nigra.
- Adult, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
OFF‐period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF‐period symptoms as well as levodopa‐induced dyskinesias. However, only GPi‐DBS led to a significant reduction of OFF‐period dyskinesias whereas STN‐DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia‐related neural activity within the basal ganglia loop. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21768
Affiliations:
- Allemagne, Suède
- Bavière, Berlin, District de Giessen, District de Haute-Bavière, Hesse (Land), Schleswig-Holstein
- Berlin, Kiel, Marbourg, Munich
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-15">2008-07-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1293">1293</biblScope><biblScope unit="page" to="1296">1296</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">CFD44A169FB44FC0155595D67CC6A8B574159CE4</idno><idno type="DOI">10.1002/mds.21768</idno><idno type="ArticleID">MDS21768</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Deep Brain Stimulation (methods)</term><term>Deep brain stimulation</term><term>Dyskinesia</term><term>Fetal Tissue Transplantation (methods)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (surgery)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Substantia Nigra (transplantation)</term><term>Transplantation</term><term>Treatment Outcome</term><term>deep brain stimulation</term><term>dyskinesias</term><term>neural transplantation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Fetal Tissue Transplantation</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Stimulation cérébrale profonde</term><term>Transplantation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OFF‐period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF‐period symptoms as well as levodopa‐induced dyskinesias. However, only GPi‐DBS led to a significant reduction of OFF‐period dyskinesias whereas STN‐DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia‐related neural activity within the basal ganglia loop. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suède</li></country><region><li>Bavière</li><li>Berlin</li><li>District de Giessen</li><li>District de Haute-Bavière</li><li>Hesse (Land)</li><li>Schleswig-Holstein</li></region><settlement><li>Berlin</li><li>Kiel</li><li>Marbourg</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name></region><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Pinsker, Marcus O" sort="Pinsker, Marcus O" uniqKey="Pinsker M" first="Marcus O." last="Pinsker">Marcus O. Pinsker</name><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></country><country name="Suède"><noRegion><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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